To develop, implement and demonstrate the capability for automatic and semi-automatic processing, analysing and annotating diagnostic features in histopathology images for the diagnosis, prognosis and treatment of breast cancer.  To compress and transmit the images based on their content without loss of diagnostic information for second opinion confirmation/diagnosis and storage of diagnostic records.  To develop a histopathology image database system to enable the management (indexing and retrieval) of breast cancer slide images by means of their histopathology meanings or features, or by their textual annotations.  To undertake clinical evaluations of the prototype systems.